Lower airway inflammation before and after house dust mite nasal challenge: An age and allergen exposure-related phenomenon
نویسندگان
چکیده
منابع مشابه
Airway remodelling and inflammation in sheep lungs after chronic airway challenge with house dust mite.
BACKGROUND Remodelling of airway walls is a significant morbidity factor in patients suffering from chronic asthma. The relationship between airway remodelling and the inflammatory response is not well defined. Sheep have been used extensively to model airway disease in humans and represent a suitable model to examine airway remodelling. OBJECTIVE The aim of the present study was to develop a...
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The variability of repeated house dust mite (HDM) allergen determinations at the same site within 3-24 months was evaluated on previously collected samples. Between two and four repeated measurements of Der p 1, a major allergen of Dermatophagoides pteronyssinus and Der f 1, a major allergen of D. farinae, on 46 carpets and 31 mattresses were analyzed. In 90% of carpets and mattresses, HDM alle...
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“At a Glance Commentary” The current dogma, based largely on indirect evidence, is that TGF-β plays a prominent role in the development of airway remodeling, a recognized feature of chronic allergic asthma. This research contributes to our understanding of the mechanisms regulating inflammation and remodeling in chronic allergic asthma, and suggests that therapeutic strategies to prevent remode...
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RATIONALE It is now believed that both chronic airway inflammation and remodeling contribute significantly to airway dysfunction and clinical symptoms in allergic asthma. Transforming growth factor (TGF)-beta is a powerful regulator of both the tissue repair and inflammatory responses, and numerous experimental and clinical studies suggest that it may play an integral role in the pathogenesis o...
متن کاملDomestic control of house dust mite allergen in children's beds.
BACKGROUND House dust mite allergen levels in humid coastal regions of Australia are high, particularly in beds. Because high allergen levels in beds are associated with more severe asthma, reduction of levels may be important for asthma control. OBJECTIVE We tested the effectiveness of an acaricidal treatment of bedding in combination with occlusive mattress and pillow encasings in reducing ...
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ژورنال
عنوان ژورنال: Respiratory Medicine
سال: 2007
ISSN: 0954-6111
DOI: 10.1016/j.rmed.2006.06.006